This paper describes the trends in glucose microsensor research and development Micromachining techniques have been applied to construct glucose sensors. Several detection methods and their modification through last 15 years are investigated. We begin with sensors which are based on photometric characteristics and continue with glucose sensitive FET. Most of the sensors use amperometricmethod with enzyme selector and some sensors apply new methods such as electro microbalance or luminescence measurements. Finally we describe MIP method for material detection that has several advantages over other methods such as high sensitivity reproducibility and durability because of its enzyme free structure. Design of our microsensor is based on MIP detection method